Dude, for MP games you just drop shadows from extreme to ultra or some other setting that makes practically no visual difference and gains you a lot of FPS.
Plus, you also have Gsync, so you don't notice the drops from 144fps to 110 or whatever so much. Gsync is a game changer as you don't have to be so worried about FPS and achieving max refresh rate for it to remain smooth.
In single player, who cares? As long as it's 70+ or so I'm fine with it, but aim for around 100FPS.
Honestly I'm running everything at 3840x1600 144hz and 4k 60hz just fine.